There's a company in my e.f. cohort who do most of their work on a box with 48GB of video memory. Another regularly spins up clusters to do machine learning on large video datasets to identify theft.
Most accelerators have partners that can get this stuff for cheap or free - including physical boxes.
It's a European accelerator that focuses on founders with deep tech (I seem to be the only person here without a doctorate in machine learning) and lets them form teams in the actual programme.
Some of the other people here are predicting (with massively higher certainty than doctors) which early-onset brain issue folks will develop alzheimers, making a standard simple way to run experiments in outer space (first launch in a few weeks), doing natural language interfaces for personal finance, and other crunchy stuff.
Most accelerators have partners that can get this stuff for cheap or free - including physical boxes.