I'm honestly not much of a karma-whore, so I'm not terribly motivated by it.
However, it occurred to me that it might be interesting to roll content creation into the karma score.
Example: Paul Buchheit writes a lot of good stuff. Other people submit it. They get points. However, if you could associate Paul's blog to his YC.News account, then you could have some of that karma attach itself to him.
Now, how to reliably "claim" a blog is a challenge. And WTF you do with a site like the BBC, Wired, SFGate, etc.
for reference: (http://searchyc.com/top/domains_by_points)