If my screen requires 250% scaling to be usable (which I am not making up - that is precisely the scaling it "recommends"), then lower resolution with pixels that are six times bigger is not a loss of quality. Large black squares composed of smaller black squares are not somehow ineffably superior to large unitary black squares.
Scaling of vector fonts in modern desktop systems doesn't work that way. Scaling is done before rasterization, and you would get perfectly sharp edges with 250% scaling.
