I currently take naltrexone with buprenorphine for my depression. I highly recommend checking out low dose naltrexone, which is usually defined as a dose less than 5 mg. There has been a large surgre of interest in LDN on /r/nootropics and /r/depressionregimens in the past six months. Most people are trying it either for autoimmune diseases or to reverse opiate tolerance. The typical starting doses for LDN are around 1 mg
Before anyone says that I'm just getting high, you should know that I've been on 20+ different antidepressant treatments and none of them worked. That includes ketamine and rTMS. So it was a medication of last resort. My other options were basically electro convulsive therapy or deep brain stimulation.
There is an experimental antidepressant called ALKS 5461 that is composed of buprenorphine and samidorphan. The company who makes it (Alkermes) recently submitted a new drug request to the FDA, but it was denied because the FDA wants more studies on how ALKS 5461 compared to buprenorphine. Samidorphan has a similar method of action to naltrexone, and the dose of samidorphan is 2 mg, combined with 2 mg of buprenorphine. If the FDA would have approved it, it would have been released in 2019.
Before anyone says that I'm just getting high, you should know that I've been on 20+ different antidepressant treatments and none of them worked. That includes ketamine and rTMS. So it was a medication of last resort. My other options were basically electro convulsive therapy or deep brain stimulation.
There is an experimental antidepressant called ALKS 5461 that is composed of buprenorphine and samidorphan. The company who makes it (Alkermes) recently submitted a new drug request to the FDA, but it was denied because the FDA wants more studies on how ALKS 5461 compared to buprenorphine. Samidorphan has a similar method of action to naltrexone, and the dose of samidorphan is 2 mg, combined with 2 mg of buprenorphine. If the FDA would have approved it, it would have been released in 2019.