So the way this is supposed to work is that providers hand out /48s and each site should be allocated a /64. In practice if you for example rent a VPS, you'll be handed a /64 for it by your service provider from their /48.
I would personally treat any /64 as the same. Depending on your local network setup the second half of the address could be anything and could change frequently. You might also get multiple addresses. Whereas getting a new /64, or /48, requires slightly more effort.
Of course there's a risk you'll block a /64 and that takes out some whole company or whatever, but I've seen that happen to corporate proxies that got flagged as a source of spam as well so this is not an easy problem even without the 2^128 address space.
I would personally treat any /64 as the same. Depending on your local network setup the second half of the address could be anything and could change frequently. You might also get multiple addresses. Whereas getting a new /64, or /48, requires slightly more effort.
Of course there's a risk you'll block a /64 and that takes out some whole company or whatever, but I've seen that happen to corporate proxies that got flagged as a source of spam as well so this is not an easy problem even without the 2^128 address space.