Yep. Once you edit the xrdp.ini file to enable the Xorg backend (which I've done recently on Fedora 36 and Ubuntu LTS), you're good.

Multiple screen support depends on your client, I've had no issues with Windows and Mac clients. Audio depends a lot on your server distro (clients have it all sorted). Fedora uses pipewire, so YMMV.

When using mobile connections I trim it down to 16-bit color and it is perfectly usable, although if you're doing that all the time I'd also remove wallpaper and shadows (I prefer using something like XFCE when doing that - https://taoofmac.com/space/blog/2022/04/12/2330).

I had to switch back to Pulseaudio and compile the audio plugin for XRDP myself (that was on Fedora 35).

You're probably right about that. My Fedora container is 36 upgraded from 35, so I might have done that a while back and never looked back.

Looks good, I'll try, thanks.