May be a part of why so many people with psychiatric disorders (especially undiagnosed or untreated) often use nicotine and/or alcohol to cope. They both interact heavily with the GABAergic system. Alcohol also inhibits the activity of glutamate and reduces extracellular levels in certain brain regions. Too much glutamate in the brain can cause 'failure of different neurotransmission systems' and is neurotoxic.
It's too bad self-medicating with these substances comes with such awful downsides.
Ethanol is my go to medication. It’s the only calcium, sodium, and potassium ion channel blocker that can enter the brain. These are implicated in bipolar disorder which I have. The trick is to not abuse it just like any other medication.
I also have labile hypertension and it’s the only medication I can take that controls my blood pressure spikes.
I feel the same way about nicotine, although I can’t take it because it turns me to up. Nicotine is a stimulant and can be used as a medicine in lower doses. The problem is that people used to do and that sets up the addiction cycle.
I definitely have an issue with a very high glutamate/GABA ratio. My other go to medicine is Klonopin which I use only when I’m in a severe crisis. Like when I had a delusional psychosis when I had Covid.
It's too bad self-medicating with these substances comes with such awful downsides.