Marijuana, like all psychoactive drugs, is known to trigger latent mental disorders, which is the primary reason it was made a controlled drug in the first place. It is also known to cause infertility in men and women due to the interaction between THC and various hormones.

It also has a number of other negative health effects (e.g., lung cancer, popcorn lung, asthma, etc.) if smoked as weed or vaped which are generally avoided if marijuana is consumed as an edible or liquid.