On Mac with a pdf I just select say a chapter and let it read. Footnotes can be a problem. I usually use iOS now and I wrote PDF before but realize I use .epub files mostly. You can set up iOS to read entire pages. I use the local iOS Books app and have it so a two-finger swipe from the top of a page starts reading. It will usually turn pages by itself but can be a bit janky. I choose a good quality voice and have spent ten or twenty minutes rigging it up in Settings.
I have tried to set up something similar with text-to-speech browsers extension but I loose my place if I have to close and reopen.