I had to stop using it at work.. I'd have to restart every 2-3 hours or performance became unbearably slow. The only other "solution" was to remove all my addons, and without the addons there was really no reason to continue using firefox (Firebug was supposedly the main issue, but without firebug I can't do any work)
I never got used to Chrome's Developer Tools. Firebug and a properly working Scrollbar Anywhere / Grab-n-drag (lets you right click anywhere and drag up and down to scroll anywhere in the page) are the only extensions keeping me on Firefox.
The equivalents on Chrome are simply not good enough. I don't know if this is an issue with all Chrome extensions, but Wet Banana / Scrollbar Anywhere on it seem to be running in a low priority and thus have sub-par performance. Scrolling is choppy and doesn't always even initiate, depending on where on the page I right-clicked.