Reminds me a bit of the UPS Flight 6 that crashed in 2010. Wasn't the cause of the fire, but the fire heated up the co-pilots oxygen system to the point he couldn't wear it and eventually succumbed to smoke hypoxia. Due to smoke in the cabin the pilot couldn't see his flight deck readouts or out the window and eventually crashed into the ground.
One would have to wonder why an emergency smoke extractor fan isn't default equipment - when pilots oxy is deployed a panel should blow outward and a high flow fan start.
blowtorch effect. depressurizing the cabin and cargo hold is on the checklist for some on-board fires, but the rushing air can produce a blowtorch and spread the fire along. see UPS flight 6 iirc.
