I live about 30 minutes from STL (or as the cool kids say: StL) so maybe I'll check out their monthly Code Til Dawn http://www.meetup.com/allnightlong/#past
Yearly
The Strange Loop Conference: https://thestrangeloop.com/
Monthly
Lambda Lounge: http://lambdalounge.org/
Saint Louis JavaScript Meetup (STLJS): http://www.stljs.org/ http://vimeo.com/stljs
STLRuby: http://stlruby.org
Code Until Dawn: http://www.meetup.com/allnightlong/
StartLouis: http://startlouis.com/
Build Guild in St. Louis: http://saintlouis.buildguild.org/
There's lots more too, those are just ones I'm either involved in or hear about frequently.
Swing by TREx sometime too (http://downtowntrex.com)
I live about 30 minutes from STL (or as the cool kids say: StL) so maybe I'll check out their monthly Code Til Dawn http://www.meetup.com/allnightlong/#past