Woah I didn't know about that theory, that's really interesting! If I understand correctly, it's that the ligand needs to both fit "physically" and also have the right vibrational mode to have high binding affinity / trigger the receptor? Sounds like the relevant frequencies would be in IR range, or roughly 10-100 terahertz. We're at 300 kHz, so 9 orders of magnitude lower, so we're likely not activating the receptors directly with that mechanism. But, maybe the acoustic radiation force from the ultrasound gives existing molecules in the air enough energy to increase the coupling? And nobody seems to really know how ultrasound neurostimulation really works, so who knows—maybe something similar even happens with neurotransmitters in cortex...
Well, if it’s waves, perhaps principles of consonance and dissonance might apply.
Robert Hooke thought so…
“Now as we find that musical strings will be moved by Unisons and Eighths, and other harmonious chords, though not in the same degree; so do I suppose that the particles of matter will be moved principally by such motions as are Unisons, as I may call them, or of equal Velocity with their motions, and by other har∣monious motions in a less degree.
I do further suppose, A subtil matter that incom∣passeth and pervades all other bodies, which is the Menstruum in which they swim which maintains and continues all such bodies in their motion, and which is the medium that conveys all Homogenious or Har∣monical motions from body to body.
Further I suppose, that all such particles of matter as are of a like nature, when not separated by others of a differing nature will remain together, and strengthen the common Vibration of them all against the differing Vibrations of the ambient bodies.
According to this Notion I suppose the whole Universe and all the particles thereof to be in a con∣tinued motion, and every one to take its share of space or room in the same, according to the bulk of its body, or according to the particular power it hath to receive, and continue this or that peculiar motion.
Two or more of these particles joyned immediately together, and coalescing into one become of another nature, and receptive of another degree of motion and Vibration, and make a compounded particle differing in nature from each of the other par∣ticles.
All bulky and sensible bodies whatsoever I suppose to be made up or composed of such particles which have their peculiar and appropriate motions which are kept together by the differing or dissonant Vibrations of the ambient bodies or fluid“
https://en.wikipedia.org/wiki/Vibration_theory_of_olfaction