I've been using Acuvue Oasys (IIRC) for a while now. I'm on the 4-week disposables but my optometrist is getting worried about increased blood vessel growth in my cornea. I think my eyes may just be particularly sensitive - this is happening despite me wearing lenses for a max of 12 hours a day and not exceeding the recommended 4 weeks of wear per lens.
I had problems with Acuvue Oasys back in the day as well, but I'm sure it varies from person to person. Ask your eye doctor to order trial pairs from different brands. That's how I eventually found the ones that worked for me.
I had permanent redeye and frequent allergic reactions when I was using Acuvue Oasys lenses. Some were pretty bad; I couldn't wear my lenses for weeks at a time and had to get $130/oz eyedrops to get rid of the irritation. After switching to a different brand of lenses the problems went away. My sister had a similar experience.