It's not especially programming or design related; but I was recently turned on to EconTalk (http://www.econtalk.org/) and it's been very enjoyable. Especially good talks were:

* Nick Bostrom on Superintelligence: http://www.econtalk.org/archives/2014/12/nick_bostrom_on.htm...

* Piketty on Inequality and Capital in the 21st Century: http://www.econtalk.org/archives/2014/09/thomas_piketty.html