"That's why I really think we should start a movement of publishing everything, and trying to deal with simpler models/systems we do understand before going up to models with so many unknowns that the results are basically a dice roll."
I would love to see this implemented, and encouraged in every lab around the world! It's not like we don't have computer programs that could collate all the data?
I don't think I will ever see this happen; because the truth is Not what companies want. They want a drug/theory they can sell. It's a money game to these pharmaceutical companies in the end. Companies, and I believe many researchers want positive results, and will hide, cherry pick the experiments/studies that prove their hypotheses? I know their must be honest, addenda free researchers out there, but I have a feeling they are not working for organizations with the money to fund serious, large scale projects?
Take for instance, Eli Lilly--whom has a history of keeping tight control over their researchers. The history of Prozac is a good example of just how money produces positive results;
"Eli Lilly, the company behind Prozac, originally saw an entirely different future for its new drug. It was first tested as a treatment for high blood pressure, which worked in some animals but not in humans. Plan B was as an anti-obesity agent, but this didn't hold up either. When tested on psychotic patients and those hospitalised with depression, LY110141 - by now named Fluoxetine - had no obvious benefit, with a number of patients getting worse. Finally, Eli Lilly tested it on mild depressives. Five recruits tried it; all five cheered up. By 1999, it was providing Eli Lilly with more than 25 per cent of its $10bn revenue."
(1) I love how Prozac was tested on mild depressives. Don't current prescribing guidelines only recommend the administration of Prozac for the most seriously ill--the clinically depressed? Actually--no, it's still recommended for for a myriad of disorders? Wasn't Prozac proved to be only slightly better than placebo? If you dig deeper, their are some sources that don't see any benefit over placebo.
(2) Wouldn't patients/society benefit from seeing all of the studies Eli Lilly presented to the FDA? Not just the favorable ones? How many lives would have been saved if this drug was given an honest evaluation--if every study was published, and put through statistical calculations in the 90's? Think about the millions of patients who suffered terrible side effects of this once terrible expensive drug? Think about the birth defects that could have been prevented?
So yes, I would love to see everything published, but I don't think the business cycle/politics will ever allow it? They want results! They want money! They want endowments! It's a sick game, until you are the one needing help. Help that only honest, good science can produce?
I would love to see this implemented, and encouraged in every lab around the world! It's not like we don't have computer programs that could collate all the data?
I don't think I will ever see this happen; because the truth is Not what companies want. They want a drug/theory they can sell. It's a money game to these pharmaceutical companies in the end. Companies, and I believe many researchers want positive results, and will hide, cherry pick the experiments/studies that prove their hypotheses? I know their must be honest, addenda free researchers out there, but I have a feeling they are not working for organizations with the money to fund serious, large scale projects?
Take for instance, Eli Lilly--whom has a history of keeping tight control over their researchers. The history of Prozac is a good example of just how money produces positive results;
"Eli Lilly, the company behind Prozac, originally saw an entirely different future for its new drug. It was first tested as a treatment for high blood pressure, which worked in some animals but not in humans. Plan B was as an anti-obesity agent, but this didn't hold up either. When tested on psychotic patients and those hospitalised with depression, LY110141 - by now named Fluoxetine - had no obvious benefit, with a number of patients getting worse. Finally, Eli Lilly tested it on mild depressives. Five recruits tried it; all five cheered up. By 1999, it was providing Eli Lilly with more than 25 per cent of its $10bn revenue."
(1) I love how Prozac was tested on mild depressives. Don't current prescribing guidelines only recommend the administration of Prozac for the most seriously ill--the clinically depressed? Actually--no, it's still recommended for for a myriad of disorders? Wasn't Prozac proved to be only slightly better than placebo? If you dig deeper, their are some sources that don't see any benefit over placebo.
(2) Wouldn't patients/society benefit from seeing all of the studies Eli Lilly presented to the FDA? Not just the favorable ones? How many lives would have been saved if this drug was given an honest evaluation--if every study was published, and put through statistical calculations in the 90's? Think about the millions of patients who suffered terrible side effects of this once terrible expensive drug? Think about the birth defects that could have been prevented?
So yes, I would love to see everything published, but I don't think the business cycle/politics will ever allow it? They want results! They want money! They want endowments! It's a sick game, until you are the one needing help. Help that only honest, good science can produce?
http://www.theguardian.com/society/2007/may/13/socialcare.me...