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Merry Christmas and Happy Holidays to all celebrating!


It seems a bit.. abrasive and brash to label this an eating disorder, no?

As a doctor and technical founder/CEO myself, I really like patients who are into their own health and fitness, obviously this guy has the means and resources to take it to an extreme, but I think the lesson he wants to impart is that there are benefits to investing in your own health, the same as people invest in self-tooling such as expensive Macbooks/Mac studios, running shoes, and much more.

The whole world would see such titan sized improvements in GDP along with personal lives. Men and women would be happier if everyone strove to be fit, "younger" (with respect to wellness and fitness) and in better shape, not to mention that would translate to very real economic benefit in every country.


The author's point is that these extremes aren't healthy and fit.


I like this reasoning. When evaluating if an individual has an eating disorder it is vital that the physician doing the evaluation spend the requisite time imagining various scenarios relating to the gross domestic product of the country they are in, or the earth as a whole


Given where his body fat and his core body temperature is these days, let's withhold judgment a bit before we crow about "titan sized improvements in GDP".

He's running an n=1 experiment well out of established parameters, and the outcome is far from guaranteed.


It's inappropriate in general to diagnose people with psych disorders based on their social media and public persona


I generally agree that we shouldn't armchair diagnose people, especially not for gossip's sake. But in this case Bryan is actively promoting a lifestyle which looks symptomatic of a disorder, so it's probably in the public interest to point that out.

The post author did so in a thoughtful and respectful manner.


Exhibiting symptoms of a disorder is not the same as having a disorder which is why it's irresponsible and inappropriate to diagnose people based on their social media.


eh eating disorders in particular have quite the social contagion. anorexia definitely spreads via social media.


Bryan clearly is not anorexic because he gained a bunch of weight/fat when his doctor told him he was at a dangerous weight. Someone suffering from anorexia is not going to increase their body fat by 5-10% on their doctors recommendation.


I'm not saying he's anorexic. I'm using it as an example of how eating disorders have a significant social contagion component to them.


GDP is a pointless metric, if we all get cancer GDP is going to go way up.


I don’t think you understand how down the rabbit hole this guy goes.

> Bryan Johnson’s supplements list includes more than 100 compounds taken as powders, tablets, and capsules, designed to support different aspects of his health.

This is an insane thing to do and I have delved deeply into supplements myself and it is stunning how hard it is to find evidence that any of them do anything beneficial long term.

This matches me own experience and daily diary of trying things, rating how I feel, bloodwork, etc. The only thing I’ve ever found beneficial long term is testosterone, sunlight, and exercise.


He sells supplements, including specific ingredients for which there isn't much evidence of efficacy. Even if you assume most of what he preaches and sells is scientific, some of it is unscientific which sort of undermines the entire pitch, I think.


Testosterone in the form of steroids and TRT? Not judging just curious.


Just trt, actually going too high >1000 feels awful to me.

Just fixing this world decline helps so much.

https://sci-hub.se/10.1016/j.euf.2020.02.006


There is also big question isn't it is more harm to the system removing its ability to produce what it should produce by itself.


Yeah, you won't find evidence for two decades because of the time and resourcing it would take to fund it, plus none of them being in metabolic wards.

You can sit around and wait for "The Science" or you can be a data point for yourself.


Uh are you a psychiatrist because it doesn't sound like it? This definitely looks like it could meet DSM criteria as an eating disorder.

To the muggles out there, generally speaking non psychiatric doctors (and many older, out of date psych professionals for that matter) know about as much about modern psych diagnostic criteria as a potato.


Seems like a more exciting Rails release than I can remember in several years.

Curious about the benefits of Propshaft vs Sprockets, and how significant the improvements around SQLite in production really are.


I think the only benefit is that it does less, so less code, less maintainance or things going wrong? But Sprockets is certainly battle tested and maybe better choice for many right now.


Haven't had the chance to look into this in depth yet, but is this a like Cloudflare pages or Vercel? Can you host static sites a la Next/Nuxt/Sveltekit/Solid etc?


Pretty crazy. Supporting 1.5mbps video calls for each human on earth? Did I read that right?

Just goes to show how drastic and extraordinary levels of scale can be.


Scale means different things to different people


I'm working on MedAngle, the world's first Super App for premed, medical, and dental students. We offer an all-in-one feature set called the Smart Suite with dozens of Smart features, and it has tens of thousands of questions, quizzes, clinical cases, and other educational content.

Best of all, we're hyper-personalized for the institution you study at, making us the first to do this in history. I get to lead a team of 175+ doctors and top tier medical/dental students.

https://medangle.com

I also am the first full-stack technologist who also is a medical doctor in the history of Pakistan, a country of 250+ million people, and have been featured on national TV and media platforms.


The internet never fails to amuse me, this is awesome haha


No, as long as you've graduated from medical school in a country that has accredited/globally recognized medical schools, you can take the steps (USMLEs), and thus you can get ECFMG certified.


Cerebras really has impressed me with their technicality and their approach in the modern LLM era. I hope they do well, as I've heard they are en-route to IPO. It will be interesting to see if they can make a dent vs NVIDIA and other players in this space.


Apparently so. You can also buy in via various PE outfits before IPO, if you so desire. I did.


Which one did you use? I am also interested to do that.


I've been thinking about doing the same, seems much more cost effective. How much will you sell the VDS for?


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